Welcome to the 7 Tesla (7T) Bioengineering Research Program (7TBRP) and the Radiofrequency (RF) Research Facility at University of Pittsburgh.

All the 7 Tesla imaging studies are performed using the Tic Tac Toe RF Coil System (16 transmit channels and 32 receive channels).  The transmit channels are combined to operate in the single transmit mode of the MRI system; no adjustments are needed between subjects.

Projects Funded By the National Institute of Health (NIH)

– Morning Activation Deficits and Depression Symptoms: Mechanisms and Modifiability in Dementia Caregivers

– Puberty-related development of fronto-amygdala circuitry in anxious youth: A multimodal neuroimaging study with ultra-high resolution MRI scanner (7T)

– Mild Cognitive Impairment: A Prospective Community Study

– Menopausal Vasomotor Symptoms and Brain Aging in Women

– Neural Systems in Auditory and Speech Categorization

– Biobehavioral Studies of Cardiovascular Disease

– Neural Systems Underlying Severe Worry in Anxious Adolescents and Young Adults

– Anesthestic Modulation of Human memory during acute pain

– Aerobic Exercise for Optimizing Cognitive and Brain Health in Remited Late-Life Depression

– Machine Learning Models for Identifying Neural Predictors of TMS Treatment Response in MDD

– A Cerebrovascular Basis for Sex Differences in Alzheimer’s Disease Risk

– Alzheimer’s Biomarker Consortium – Down Syndrome (ABC – DS)

– Bioengineering in Psychiatry Training Program

– Visceral Neural Circuits Linking Childhood Threat and Deprivation with Stress Physiology and Affective Symptoms in a Transdiagnostic Sample Using High-Field Personalized Brain Mapping

– Imaging Advancements in Small Vessel and CSF Flow Pathophysiology of Pre-clinical Alzheimer’s Disease

– Synaptic Pruning and Complement Gene in Schizophrenia: Imaging & Cellular Studies

– Metabolic and Inflammatory Pathways of Midlife Neurocognitive Disparities

– Menopausal Vasomotor Symptoms and Brain Aging in Women

– Functional Neuroanatomy Correlates of Worry in Older Adults

– Neural Mechanisms of Monoaminergic Engagement in Late-Life Depression Treatment Response (NEMO)

– Evaluation of Brain and Cognitive Changes in Older Adults with MCI Taking Lithium to Prevent Alzheimer Type Dementia

– Depression in dementia caregivers: Linking Brain Structure and Sleep-Wake Risks

– Neural Mechanisms of Monoaminergic Engagement in Late-Life Depression Treatment Response (NEMO)

– Dimensional Outcomes and Neural Circuitry Associated with Psychosis Risk

– High Performance Imaging for Assessment of Small Vessel Disease in Older Adults with Depression

– Neurovascular Determinants of Cognitive Function in Adults with Sickle Cell Disease

– High Performance Imaging for Assessment of Small Vessel Disease in Older Adults with Depression (Supplement focused on AD and AD Related Pathology)

– Biobehavioral Mechanisms Linking Personality to Health in Midlife

– Roles of Gray Matter Brain Aging and Small Vessel Disease in AD Pathophysiology

– High Performance Imaging for Assessment of Small Vessel Disease in Older Adults with Depression (Supplement focused Pre-Doc Training in Resting State fMRI and RF Coil Design)

Projects Supported by Other Funding

Investigating the Link Between Pre-Clinical Alzheimer’s disease and Postoperative Cognitive Dysfunction Using Functional Neuroimaging

Narrative: The goal of this pilot project is to develop a 7T functional neuroimaging program of postoperative cognitive dysfunction.
Funding Agency: University of Pittsburgh Physicians Academic Foundation

Neural Correlates of Auriculotherapy

Funding Agency: University of Pittsburgh Department of Anesthesiology Seed Grant

Neural Circuitry Resilience in Psychotic Disorders: A Multimodal Ultra-High Field Neuroimaging Study

Funding Agency: Department of Veterans Affairs

Toward Understanding Neural Substrates of Worry in Adolescents and Adults

Funding Agency: CTSI REAL Pilot Program

In Vivo Staging of Prodromal and Early Stage Parkinson’s Disease Pathology 

Funding Agency: SOM Dean’s Faculty Advancement Award

Investigating the Link Between Pre-Clinical Alzheimer’s Disease and Postoperative Cognitive Dysfunction using Functional Neuroimaging

Funding Agency: University of Pittsburgh Physicians Academic Foundation

Novel Imaging Strategies of Cerebrovascular Dysfunction in Sickle Cell Disease

Funding Agency:University of Pittsburgh Vascular Medicine Institute

Completed Projects