Tales Santini

Research Assistant Professor
PhD in Bioengineering

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Major Projects:

Electromagnetic simulations of innovative RF coil designs for 7T MRI:

  • Foot/ankle transmit RF coil
  • 16-channel transmit head RF coil
  • 16-channel transmit body RF coil
  • 28-channel transmit head RF coil

Optimization of multi-channel RF coils (RF shimming):

  • 16-channel head coil
  • 28-channel head coil

High-resolution image acquisition at 7T MRI

  • Foot/ankle RF coil
  • 16-channel head coil

Post-processing of in-vivo human MRI data:

  • Functional MRI (task-based)
  • Diffusion MRI and fiber tracking
  • Image denoising
  • Hippocampus subfields and brain segmentation

Publications

  1. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tiago Martins, Howard J. Aizenstein, Tamer S. Ibrahim. Improved 7 Tesla Transmit Field Homogeneity with Reduced Electromagnetic Power Deposition Using Coupled Tic Tac Toe Antennas. Scientific Reports (accepted).
  2. Tales Santini, Minseok Koo, Nadim Farhat, Vinicius P. Campos, Salem Alkhateeb, Marcelo A. C. Vieira, Meryl A. Butters, Caterina Rosano, Howard J. Aizenstein, Joseph Mettenburg, Enrico M. Novelli, Tamer S. Ibrahim. Analysis of Hippocampal Subfields in Sickle Cell Disease Using Ultrahigh Field MRI. (under review).
  3. Sossena Wood, Tales Santini, Narayanan Krishnamurthy, Tiago Martins, Nadim Farhat, Tamer S. Ibrahim. A Comprehensive Electromagnetic Evaluation of an MRI Anthropomorphic Head Phantom. NMR in Biomedicine (2020).
  4. Nadim S. Farhat, Robert Theiss, Tales Santini, Tamer S. Ibrahim, Howard J. Aizenstein. Recent advances in Neuroimaging of Small Vessel Disease in Late-life Depression. Advances in Experimental Medicine and Biology (AEMB), book series of Springer, 2019.
  5. Stephen F Smagula, Sarah T Stahl, Tales Santini, Layla Banihashemi, Martica H Hall, Tamer S Ibrahim, Charles F Reynolds III, Robert T Krafty, Howard J Aizenstein, Liang Zhan. “White matter integrity underlying depressive symptoms in dementia caregivers”. The American Journal of Geriatric Psychiatry (2019)
  6. Narayanan Krishnamurthy*, Tales Santini*, Junghwan Kim, Sossena Wood, Howard Aizenstein, and Tamer S. Ibrahim. “Computational and Experimental Evaluations of transmission line Based RF Coils at 7T”. PlosOne, 2019. *equal contribution.
  7. Melania Borges, Marcelo Prado, Tales Santini, Adriano Barbosa, Antonio Moreira, Issao Ishibe, Marcelo Katz, Fatima Cintra. Development and clinical validation of a non-invasive, beat-to-beat blood pressure monitoring device, compared to invasive blood pressure monitoring during coronary angiography. Einstein Journal 2019.
  8. Tales Santini, Yujuan Zhao, Sossena Wood, Narayanan Krishnamurthy, Junghwan Kim, Nadim Farhat, Tiago Martins, Tiejun Zhao, Howard Aizenstein, and Tamer S. Ibrahim. “In-vivo and numerical analysis of the eigenmodes produced by a multi-level head transmit array for 7 Tesla MRI” PlosOne, 2018.
  9. Tales Santini, Junghwan Kim, Sossena Wood, Narayanan Krishnamurthy, Nadim Farhat, Carlos Maciel, Shailesh Raval, Tamer Ibrahim. “A new RF Transmit Coil for Foot and Ankle Imaging at 7T MRI.” Magnetic Resonance Imaging, 2018.
  10. Stephen Smagula, Helmet Karim, Anusha Rangarajan, Fernando Santos, Sossena Wood, Tales Santini, John Jakicic, Charles Reynolds III, Judy Cameron, Abbe Vallejo, Meryl Butters, Caterina Rosano, Tamer Ibrahim, Kirk Erickson, Howard Aizenstein. “Association of hippocampal substructure resting-state functional connectivity with memory performance in older adults,” American Journal of Geriatric Psychiatry, 2018.
  11. Kim, Junghwan, Tales Santini, Kyongtae Ty Bae, Narayan Krishnamurthy, Yujuan Zhao, Tiejun Zhao, and Tamer S. Ibrahim. “Development of a 7 T RF coil system for breast imaging.” NMR in Biomedicine 2017.
  12. Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Nadim Farhat, John Andy Holmes, Tamer S. Ibrahim. “Design and fabrication of a realistic anthropomorphic heterogeneous head phantom for MR purposes”. PLoS ONE 2017.
  13. Shailesh Raval, Cynthia A. Britton, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay Gorantla, Tamer Ibrahim. “Ultra-high field upper extremity peripheral nerve and non-contrast enhanced vascular imaging.” PloS ONE, 2017.
  14. Tales Santini, Tamer Ibrahim, Carlos Maciel. “Load-insensitive active quasi-circulator for continuous-wave Doppler ultrasound applications.” Electronics Letters, 2016.
  15. Junghwan Kim, Narayan Krishnamurthy, Tales Santini, Yujuan Zhao, Tiejun Zhao, Kyongtae Ty Bae, and Tamer S. Ibrahim. “Experimental and numerical analysis of B1+ field and SAR with a new transmit array design for 7T breast MRI.” Journal of Magnetic Resonance, 2016.
  16. Shailesh B. Raval, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Cynthia Britton, Vijay S. Gorantla, Tamer S. Ibrahim. “Ultra-high-field RF coil development for evaluating upper extremity imaging applications.” NMR Biomed, 2016
  17. Miguel Filho, Alexandre R. Marra, Thyago Magnus, Rodrigo Rodrigues, Marcelo Prado, Tales Santini, Elivane Victor, Eder Ishibe, Oscar Santos, Michael Edmond. “Comparison of human and electronic observation for the measurement of compliance with hand hygiene.” American Journal of Infection Control, 2014.

Conference proceedings

  1. Brendan Muldoon, Nicholas Theis, Tamer Ibrahim, Tales Santini, Matcheri Keshavan, Satish Iyengar, Shaun Eack, Vishwajit Nimgaonkar, Konasale Prasad. Altered Trisynaptic Hippocampal Network Regions in Psychosis Risk States: An Integrated Hippocampal Shape and Subregion Study Using Ultra-High Field MRI Data. Biological Psychiatry 2020
  2. Alexander Saunders, Tales Santini, Tiago Martins, Howard Aizenstein, John C. Wood, Matthew Borzage, Tamer S. Ibrahim. Performance of Automatic Cerebral Arterial Segmentation of MRA Images Improves at Ultra-high Field. ISMRM 2020.
  3. Stephen Smagula, Tales Santini, Sarah Stahl, Tamer Ibrahim, Charles Reynolds, Richard Schulz, Layla Banihashemi, Liang Zhan. White Matter Integrity Underlying Subsyndromal Depression Symptoms in Dementia Caregivers. Gerontological Society of America annual meeting, Austin, TX, 2019
  4. Matthew Saich, Tales Santini, Neilesh Vinjamuri, Tiago Martins, Zachary Fritts, Minseok Koo, Salem Alkhateeb, Nadim Farhat, Tamer S. Ibrahim. Construction and Testing of the 4-channel Microstrip Tic-Tac-Toe RF coil Design for 7T MRI. BMES 2019
  5. Danesh Thirukumaran, Tales Santini, Sossena Wood, Nadim Farhat, Salem Alkhateeb, Tiago Martins, Howard Aizenstein, Enrico Novelli, Tamer S. Ibrahim. Utilization of DTI analysis for Sickle Cell Disease related Cerebral Infarction. BMES 2019
  6. Tales Santini, Sossena Wood, Howard J. Aizenstein, Tamer S. Ibrahim. “Homogenous 64-channel RF transmit array for brain imaging at 7T, 9.4T, and 10.5T.” ISMRM 2019
  7. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tiago Martins, Nadim Farhat, Salem Alkhateeb, Howard J. Aizenstein, Tamer S. Ibrahim. “Optimization of RF system for homogenous, consistent, and safe neuro imaging at 7T MRI” ISMRM 2019
  8. Nadim Farhat, Helmet Karim, Tales Santini, Neilesh Vinjamuri, Howard Aizenstein, Enrico M Novelli, Tamer Ibrahim. “Default mode networks connectivity characterization in young adults with sickle cell disease using 7T resting functional magnetic resonance imaging.” ISMRM 2019
  9. Tales Santini, Fabrício Brito, Sossena Wood, Tiago Martins, Joseph Mettenburgh, Howard Aizenstein, Marcelo Vieira, Tamer S. Ibrahim. “Noise mitigation from high-resolution 7T MRI images” In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  10. Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Yutong Zhang, Howard Aizenstein, Tamer S. Ibrahim. “New optimization strategies for RF shimming at UHF MRI” In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  11. Tales Santini, Yujuan Zhao, Sossena Wood, Junghwan Kim, Nadim Farhat, Narayanan Krishnamurthy, Tiejun Zhao, Tamer S. Ibrahim. “Experimental and Numerical Evaluations of Simultaneously Excited Eigenmodes in a 20-channel Transmit RF Array for 7 Tesla human MRI”. In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France, 2018.
  12. Sossena Wood, Tales Santini, Nadim Farhat, Tiago Martins, Narayanan Krishnamurthy, Tamer Ibrahim. “B1+ and Temperature Analysis in Two UHF RF Coils”, In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France; 2018.
  13. Sossena Wood, Tales Santini, Narayanan Krishnamurthy, Tiago Martins, Tamer Ibrahim. “Comparison of Electric and B1+ Fields for Heterogeneous and Homogeneous Anthropomorphic Phantoms and Anatomical Models: Numerical Simulations and Experimental Findings”, In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France; 2018.
  14. Minseok Koo, Tales Santini, Neilesh Vinjamuri, Sossena Wood, Nadim Farhat, Tiago Martins, Salem Alkhateeb, Tamer S. Ibrahim. “Building and Testing of the 64-channel Radio Frequency (RF) Head Coil for Ultra-High Field MRI Applications” BMES 2018
  15. Nadim Farhat, Julia Kofler, Tales Santini, Sossena Wood, Tiago Martins, Salem Alkhateeb, Shane McKeon, Howard Aizenstein, and Tamer S. Ibrahim. Utility of 7T postmortem MRI in investigating Alzheimer’s Disease. Aging Institute research day, University of Pittsburgh, Pittsburgh, USA, 2018.
  16. Sossena Wood, Tiago Martins, Tales Santini, Tamer Ibrahim, “An electrically conductive SLA resin used for the Design of Anthropomorphic Phantoms”, In Proc. of the 26th International Society of Magnetic Resonance in Medicine Annual Meeting, Paris, France; 2018.
  17. Shane D. McKeon, Anusha Rangarajan, Minjie Wu, Nadim Farhat, Tales Santini, Sossena Wood, Tamer Ibrahim, Milos Ikonomovic, Julia Kofler, Oscar Lopez, Bill Klunk, Howard Aizenstein. “Co-registration of MRI-defined White Matter Lesions with Ex-Vivo Histopathology” BMES 2018.
  18. Tales Santini, Junghwan Kim, Sossena Wood, Naraynan Krishnamurthy, Shailesh Raval, Tamer Ibrahim,. “A new RF coil for foot and ankle imaging at 7T MRI.” In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  19. Tales Santini, Narayanan Krishnamurthy, Sossena Wood, Shailesh Raval, Yujuan Zhao, Anthony Fischetti, Minseok Koo, Howard Aizenstein, Tamer Ibrahim. “64-channel Double-Octagon Tx Head Coil for 7T Imaging.” In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  20. Tamer Ibrahim, Tales Santini, Shailesh Raval, Narayanan Krishnamurthy, Sossena Wood, Junghwan Kim, Yujuan Zhao, Xiaoping Wu, Essa Yacoub, Howard Aizenstein, Tiejun Zhao. “Towards Homogenous 7T Neuro Imaging: Findings and Comparisons between 7T TTT and NOVA RF Coil Systems.” In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  21. Shailesh Raval, Tales Santini, Sossena Wood, Narayanan Krishnamurthy, Tamer Ibrahim, “In-vivo (8×4) 32-ch Tx-only Body Array for UHF MR.” In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  22. Neilesh Vinjamuri, Tales Santini, Sossena Wood, Tamer S. Ibrahim. “Optimizing geometry of a 64-channel RF head coil”. BMES 2017
  23. Sossena Wood, Narayanan Krishnamurthy, Tales Santini, Shailesh Raval, Tamer Ibrahim. “Evaluation of an Anthropomorphic Phantom with In-Vivo Using Quantitative MRI.” In Proc. of the 25th International Society of Magnetic Resonance in Medicine Annual Meeting, Honolulu, Hawaii, April 2017.
  24. Shane D. McKeon, Anusha Rangarajan, Minjie Wu, Tales Santini, Tamer S Ibrahim, Oscar Lopez, Howard Aizenstein. “Evaluation of Segmentation Performance with 3T and 7T Magnetic Resonance Imaging using FreeSurfer”. BMES 2017
  25. Shane D. McKeon, Naomi Joseph, Anusha Rangarajan, Minjie Wu, Nadim Farhat, Tales Santini, Sossena Wood, Tamer Ibrahim, Milos Ikonomovic, Julia Kofler, Oscar Lopez, Bill Klunk, Howard Aizenstein. “Co-Registration of In-Vivo and Ex-Vivo Human MRI Brain Images”. BMES 2017
  26. Fernando P. Santos, Stephen F. Smagula, Helmet Karim, Tales Santini, Howard J. Aizenstein, Tamer S. Ibrahim, and Carlos D. Maciel. “Dynamic Bayesian Network Modeling of Hippocampal Subfields Connectivity with 7T ” Biosignals, 2016.
  27. Narayanan Krishnamurthy, Yujuan Zhao, Tales Santini, Sossena Wood, Tiejun Zhao, and Tamer Ibrahim. “Case Studies of 7T RF Shimming using Parallel Tx & Rx System.” International Society for Magnetic Resonance in Medicine, 2015.
  28. Narayanan Krishnamurthy, Yujuan Zhao, Shailesh Raval, Junghwan Kim, Sossena Wood, Tales Santini, Tiejun Zhao, and Tamer S. Ibrahim. “7T Multi-slab Whole-Head Homogenous and Low SAR T2 Acquisitions with Limited RF Power Amplifiers Capabilities.” International Society for Magnetic Resonance in Medicine, 2015.
  29. Shailesh Raval, Tiejun Zhao, Narayanan Krishnamurthy, Tales Santini, Vijay S. Gorantla, and Tamer S. Ibrahim. “Upper extremity neural and vascular imaging with UHF 7T MRI.” International Society for Magnetic Resonance in Medicine, 2015.
  30. Tales Santini, Carlos Maciel. “Project of an Active Circulator for Doppler Ultrasound Systems Application.” Brazilian Congress of Automation, 2012.

Patents

  1. Marra, et al. “System and a method for monitoring hand sanitizing opportunities in hospital wards.” US 9679464 B2, 2017. Available at https://patents.google.com/patent/US9679464
  2. Marra, et al. “System and method of monitoring physical contact events in a hospital environment”, US 10074264 B2, 2018. Available at https://patents.google.com/patent/US20180144609A1
  3. Marra, et al. “System and method of monitoring patients in hospital beds”, application number US 20180049677 A1. Submitted in 2017. Available at https://patents.google.com/patent/US20180049677A1
  4. Prado, et al. “Portable device for the analysis of skin traumas and method for analyzing skin traumas using a portable device” Available at https://patents.google.com/patent/US20180042487A1
  5. Marra, et al. “System and method for detecting the physical contact events in a hospital environment, and use of the human body as a means for transmitting an identification signal in a system for detecting the physical contact events in a hospital environment” Available at https://patents.google.com/patent/US10629301B2/en

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